Inflammatory pathways in subtypes of intestinal cancer
Prof. Dr. med. Dieter Saur
Technical University of Munich
School of Medicine
Internal Medicine II(link is external)
Institute of Translational Cancer Research and Experimental Cancer Therapy(link is external)
TranslaTUM(link is external)
Project Summary
Inflammatory signals induced by tumor cells or the host environment are closely linked to cancer progression and treatment resistance. Our preliminary data suggest that the mutational make-up of the primary tumor dictates the pro- and anti-tumorigenic immune response, which in turn determines tumor progression and survival. We aim to systematically decipher inflammatory pathways in subtypes of intestinal cancer and to evaluate the contribution of different immune cell subsets and inflammatory signals to cancer initiation and progression.
Why do alterations of certain genes cause cancer only in specific organs of the human body?
Prof. Roland Rad and Prof. Dieter Saur were awarded the German Cancer Prize 2019 in the "Experimental Research" category at the international AEK Congress in Heidelberg.
Zecha, J., Bayer, F. P., Wiechmann, S., Woortman, J., Berner, N., Müller, J., Schneider, A., Kramer, K., Abril-Gil, M., Hopf, T., Reichart, L., Chen, L., Hansen, F. M., Lechner, S., Samaras, P., Eckert, S., Lautenbacher, L., Reinecke, M., Hamood, F., Prokofeva, P., Vornholz, L., Falcomatà, C., Dorsch, M., Schröder, A., Venhuizen, A., Wilhelm, S., Médard, G., Stoehr, G., Ruland, J., Grüner, B. M., Saur, D., Buchner, M., Ruprecht, B., Hahne, H., The, M., Wilhelm, M. & Kuster, B. (2023). Science, 380, 93-101.
DOI:10.1126/science.ade3925(link is external)
Swietlik, J. J., Bärthel, S., Falcomatà, C., Fink, D., Sinha, A., Cheng, J., Ebner, S., Landgraf, P., Dieterich, D. C., Daub, H., Saur, D. & Meissner, F. (2023). Nat Commun, 14, 2642.
DOI:10.1038/s41467-023-38171-8(link is external)
Groll, T., Silva, M., Sarker, R.S.J., Tschurtschenthaler, M., Schnalzger, T., Mogler, C., Denk, D., Scholch, S., Schraml, B.U., Ruland, J., Rad, R., Saur, D., Weichert, W., Jesinghaus, M., Matiasek, K., Steiger, K. (2022). Cancers (Basel) 14.
DOI:10.3390/cancers14092248 (link is external)
Dong, J., Yetisen, A.K., Dong, C., Brändle, F., Wang, Q., Jakobi, M., Saur, D., Koch, A.W. (2021). ASC Photonics.
DOI:10.1021/acsphotonics.1c01124 (link is external)
Jesinghaus, M., Schmitt, M., Lang, C., Reiser, M., Scheiter, A., Konukiewitz, B., Steiger, K., Silva, M., Tschurtschenthaler, M., Lange, S., Foersch, S., Becker, K. F., Saur, D., Friess, H., Halfter, K., Engel, J., Boxberg, M., Pfarr, N., Wilhelm, D., Weichert, W. (2021). Am J Surg Pathol 45, 969-978.
DOI:10.1097/PAS.0000000000001692(link is external)
Yim, J. J., Harmsen, S., Flisikowski, K., Flisikowska, T., Namkoong, H., Garland, M., van den Berg, N. S., Vilches-Moure, J. G., Schnieke, A., Saur, D., Glasl, S., Gorpas, D., Habtezion, A., Ntziachristos, V., Contag, C. H., Gambhir, S. S., Bogyo, M., Rogalla, S. (2021). Proc Natl Acad Sci U S A 118.
DOI:10.1073/pnas.2008072118(link is external)
Mueller, S., Lange, S., Collins, K. A. N., Krebs, S., Blum, H., Schneider, G., Rad, L., Saur, D., Rad, R. (2020). Nat Commun 11, 4474.
DOI:10.1038/s41467-020-18095-3(link is external)
Biederstadt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H. P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Muller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G., Keller, U. (2020). Gut 69, 1472-1482.
DOI:10.1136/gutjnl-2018-317856(link is external)
Weber, J., Braun, C. J., Saur, D., Rad, R. (2020). Nat Rev Cancer.
DOI:10.1038/s41568-020-0275-9(link is external)
Lange, S., Engleitner, T., Mueller, S., Maresch, R., Zwiebel, M., Gonzalez-Silva, L., Schneider, G., Banerjee, R., Yang, F. T., Vassiliou, G. S., Friedrich, M. J., Saur, D., Varela, I., Rad, R. (2020). Nat Protoc 15, 266-315.
DOI:10.1038/s41596-019-0234-7(link is external)
Rogalla, S., Flisikowski, K., Gorpas, D., Mayer, A. T., Flisikowska, T., Mandella, M. J., Ma, X. P., Casey, K. M., Felt, S. A., Saur, D., Ntziachristos, V., Schnieke, A., Contag, C. H., Gambhir, S. S., Harmsen, S. (2019). Adv Funct Mater 29.
DOI:10.1002/adfm.201904992(link is external)
Falcomatà, C., Barthel, S., Schneider, G., Saur, D., Veltkamp, C. (2019). Curr Opin Genet Dev 54, 97-104.
DOI: 10.1016/j.gde.2019.04.002(link is external)
Weber, J., de la Rosa, J., Grove, C.S., Schick, M., Rad, L., Baranov, O., Strong, A., Pfaus, A., Friedrich, M.J., Engleitner, T., Lersch, R., Ollinger, R., Grau, M., Menendez, I.G., Martella, M., Kohlhofer, U., Banerjee, R., Turchaninova, M.A., Scherger, A., Hoffman, G.J., Hess, J., Kuhn, L.B., Ammon, T., Kim, J., Schneider, G., Unger, K., Zimber-Strobl, U., Heikenwalder, M., Schmidt-Supprian, M., Yang, F., Saur, D., Liu, P., Steiger, K., Chudakov, D.M., Lenz, G., Quintanilla-Martinez, L., Keller, U., Vassiliou, G.S., Cadinanos, J., Bradley, A., Rad, R. (2019). Nat Commun 10, 1415.
DOI: 10.1038/s41467-019-09180-3(link is external)