Characterization of aberrant immune signals driven by inflammatory cell death in cancer
Prof. Dr. med. Philipp J. Jost
Technical University of Munich
School of Medicine
Department of Hematology and Oncology(link is external)
Project Summary
In project P10, myeloid leukemias will be used as models of transformed innate cells that retain the capacity to sense inflammation in order to investigate consequences of aberrant inflammatory signal integration and necroptotic cell death on malignant transformation. To drive chronic leukocyte activation and to investigate the roles of distinct TNF receptor and necroptotic pathways on oncogenesis in vivo, as well as the functions of coordinated cytokine signaling within leukemia initiating cells, they will utilize mice expressing an AML-associated mutation in the gene encoding the FLT3 cytokine receptor.
Dill, V., Wagner, C. V., Keller, E. C., Fernandez-Hernandez, F. J., Shoumariyeh, K., Odinius, T. O., Buschhorn, L., Hauch, R. T., Suren, C., Hecker, J. S., Herhaus, P., Sandherr, M., Schmidt, B., Slotta-Huspenina, J., Bassermann, F., Höckendorf, U., Jilg, S., Branca, C., Vosberg, S. & Jost, P. J. (2023). Blood Adv, 7, 1219-1224.
DOI:10.1182/bloodadvances.2021006838(link is external)
Baumgart, L., Barz, M., Delbridge, C., Aftahy, A. K., Janssen, I. K., Jost, P. J., Ryang, Y. M., Meyer, B., Gempt, J. (2022). Curr Oncol 29, 6236-6244.
DOI:10.3390/curroncol29090490(link is external)
Reissig, T.M., Uhrig, S., Jost, P.J., Luchini, C., Vicentini, C., Liffers, S.T., Allgauer, M., Adsay, V., Scarpa, A., Lawlor, R.T., Frohling, S., Stenzinger, A., Kloppel, G., Schildhaus, H.U., Siveke, J.T. (2022). Virchows Arch.
DOI:10.1007/s00428-022-03349-w(link is external)
Wahida, A., Muller, M., Hiergeist, A., Popper, B., Steiger, K., Branca, C., Tschurtschenthaler, M., Engleitner, T., Donakonda, S., De Coninck, J., Ollinger, R., Pfautsch, M.K., Muller, N., Silva, M., Usluer, S., Thiele Orberg, E., Bottcher, J.P., Pfarr, N., Anton, M., Slotta-Huspenina, J.B., Nerlich, A.G., Madl, T., Basic, M., Bleich, A., Berx, G., Ruland, J., Knolle, P.A., Rad, R., Adolph, T.E., Vandenabeele, P., Kanegane, H., Gessner, A., Jost, P.J., Yabal, M. (2021). Sci Immunol 6, eabf7235.
DOI:10.1126/sciimmunol.abf7235(link is external)
Barz, M., Aftahy, K., Janssen, I., Ryang, Y.M., Prokop, G., Combs, S.E., Jost, P.J., Meyer, B., Gempt, J. (2021). Curr Oncol 28, 3891-3899.
DOI:10.3390/curroncol28050332(link is external)
Odinius, T.O., Buschhorn, L., Wagner, C., Hauch, R.T., Dill, V., Dechant, M., Buck, M.C., Shoumariyeh, K., Moog, P., Schwaab, J., Reiter, A., Brockow, K., Gotze, K., Bassermann, F., Hockendorf, U., Branca, C., Jost, P.J., Jilg, S. (2021). J Cancer Res Clin Oncol.
DOI:10.1007/s00432-021-03827-9(link is external)
Wang, X., Ros, U., Agrawal, D., Keller, E. C., Slotta-Huspenina, J., Dill, V., Shen, B., Shi, R., Herold, T., Belka, C., Misra, R., Bassermann, F., Garcia-Saez, A. J., Jost, P. J. (2021). Cell Death Differ.
DOI:10.1038/s41418-021-00811-1(link is external)
Jayavelu, A. K., Schnoder, T. M., Perner, F., Herzog, C., Meiler, A., Krishnamoorthy, G., Huber, N., Mohr, J., Edelmann-Stephan, B., Austin, R., Brandt, S., Palandri, F., Schroder, N., Isermann, B., Edlich, F., Sinha, A. U., Ungelenk, M., Hubner, C. A., Zeiser, R., Rahmig, S., Waskow, C., Coldham, I., Ernst, T., Hochhaus, A., Jilg, S., Jost, P. J., Mullally, A., Bullinger, L., Mertens, P. R., Lane, S. W., Mann, M., Heidel, F. H. (2020). Nature 588, 157-163.
DOI:10.1038/s41586-020-2968-3(link is external)
Munkhbaatar, E., Dietzen, M., Agrawal, D., Anton, M., Jesinghaus, M., Boxberg, M., Pfarr, N., Bidola, P., Uhrig, S., Hockendorf, U., Meinhardt, A. L., Wahida, A., Heid, I., Braren, R., Mishra, R., Warth, A., Muley, T., Poh, P. S. P., Wang, X., Frohling, S., Steiger, K., Slotta-Huspenina, J., van Griensven, M., Pfeiffer, F., Lange, S., Rad, R., Spella, M., Stathopoulos, G. T., Ruland, J., Bassermann, F., Weichert, W., Strasser, A., Branca, C., Heikenwalder, M., Swanton, C., McGranahan, N., Jost, P. J. (2020). Nat Commun 11, 4527.
DOI:10.1038/s41467-020-18372-1(link is external)
Muller, N., Fischer, J.C., Yabal, M., Haas, T., Poeck, H., Jost, P.J. (2019). Eur J Immunol 49, 504-507.
DOI: 10.1002/eji.201847818(link is external)